茨城大学理学部生物科学コース　中村麻子研究室（発がん制御研究室）

学術論文（抜粋）

  • Oizumi T, Suzuki T, Kobayashi J, Nakamura AJ. Senescence-Associated Heterochromatin Foci Suppress γ-H2AX Focus Formation Induced by Radiation Exposure. Int J Mol Sci. 2024 Mar 15;25(6):3355. doi: 10.3390/ijms25063355.
  • Shinoda H, Higano R, Oizumi T, Nakamura AJ, Kamijo T, Takahashi M, Nagaoka M, Sato Y, Yamaguchi A. Albumin Hydrogel-Coated Mesoporous Silica Nanoparticle as a Carrier of Cationic Porphyrin and Ratiometric Fluorescence pH Sensor. ACS Appl Bio Mater. 2024 Feb 19;7(2):1204-1213. doi: 10.1021/acsabm.3c01103
  • Someya M, Hasegawa T, Nakamura AJ, Tsuchiya T, Kitagawa M, Gocho T, Mafune S, Ikeuchi Y, Tauchi H, Sakata KI. Prediction of late adverse events in pelvic cancer patients receiving definitive radiotherapy using radiation-induced gamma-H2AX foci assay. J Radiat Res. 2023 Nov 21;64(6):948-953. doi: 10.1093/jrr/rrad079.
  • Nakamura AJ. Beyond visualization of DNA double-strand breaks after radiation exposure. Int J Radiat Biol. 2022;98(3):522-527. doi: 10.1080/09553002.2021.1930268.
  • Sakama S, Kurusu K, Morita M, Oizumi T, Masugata S, Oka S, Yokomizo S, Nishimura M, Morioka T, Kakinuma S, Shimada S and Nakamura AJ.An Enriched Environment Alters DNA Repair and Inflammatory Responses After Radiation Exposure.Front. Immunol. 22 October 2021 :doi.org/10.3389/fimmu.2021.760322.
  • Matsumoto H, Shimada Y, Nakamura AJ, Usami N, Ojima M, Kakinuma S, Shimada M, Sunaoshi M, Hirayama R, Tauchi H. Health effects triggered by tritium: how do we get public understanding based on scientifically supported evidence? J Radiat Res. 2021 Apr 28:rrab029. doi: 10.1093/jrr/rrab029.
  • Oizumi T, Ohno R, Yamabe S, Funayama T, Nakamura AJ. Repair Kinetics of DNA Double Strand Breaks Induced by Simulated Space Radiation. Life (Basel). 2020 Dec 10;10(12):341. doi: 10.3390/life10120341.
  • Hitomi K, Okada R, Loo TZ, Miyata K, Nakamura AJ, Takahashi A. DNA damage regulates senescence-associated extracellular vesicle release via the ceramide pathway to prevent excessive inflammatory responses. Int J Mol Sci. (2020) May 25;21(10):3720. doi: 10.3390/ijms21103720.
  • Sun L, Igarashi T, Tetsuka R, Li YS, Kawasaki Y, Kawai K, Hirakawa H, Tsuboi K, Nakamura AJ, Moritake T. Pilot clinical study of ascorbic acid treatment in cardiac catheterization. J Radiat Res. (2019) Jun 28. doi:10.1093/jrr/rrz038.
  • Nakamura AJ, Suzuki M, Redon CE, Kuwahara Y, Yamashiro H, Abe Y, Takahashi S, Fukuda T, Isogai E, Bonner WM, Fukumoto M. The causal relation between DNA damage induction in bovine lymphocytes and the Fukushima nuclear power plant accident. Radiat Res. 2017 Feb 27. doi: 10.1667/RR14630.1.
  • Kumari D, Hayward B, Nakamura AJ, Bonner WM, Usdin K. Evidence for chromosome fragility at the frataxin locus in Friedreich ataxia. Mutat Res. (2015) 781:14-21.
  • Appleman L, Balasubramaniam S, Parise RA, Bryla C, Redon CE, Nakamura AJ, Bonner WM, Wright JJ, Piekarz RL, Kohler DR, Jiang Y, Belani CP, Eiseman J, Chu E, Beumer JH, Bates SE. A Phase I Study of DMS612, a Novel Bi-functional Alkylating Agent. Clin Cancer Res. (2015) 21(4):721-9.
  • Georgakilas AG, Redon CE, Ferguson NF, Kryston TB, Parekh P, Dickey JS, Nakamura AJ, Mitchell JB, Bonner WM, Martin OA. Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant tempol. Cancer Lett. (2014) 3835(14): 00381-4.
  • Dickey JS, Gonzalez Y, Aryal B, Mog S, Nakamura AJ, Redon CE, Baxa U, Rosen E, Cheng G, Zielonka J, Parekh P, Mason KP, Joseph J, Kalyanaraman B, Bonner WM, Herman E, Shacter E, Rao VA. Mito-Tempol and Dexrazoxane Exhibit Cardioprotective and Chemotherapeutic Effects through Specific Protein Oxidation and Autophagy in a Syngeneic Breast Tumor Preclinical Model. PloS One (2013) 8(8) e70575.
  • Redon CE, Nakamura AJ, Gouliaeva K, Rahman A, Blakely WF and Bonner WM. Qg-H2AX, an analysis method for partial-body radiation exposure using gamma-H2AX in non-human primate lymphocytes. Radiat. Meas. (2011) 46:877-881.
  • Jackson-Baird B, Dickey JS, Nakamura AJ, Redon CE, Parekh P, Griko YV, Aziz K, Georgakilas AG, Bonner WM, Sedelnikova OA. Hypothermia postpones DNA damage repair in irradiated cells and protects against cell killing. Mutation Res. (2011) 711:142-149.
  • Redon CE, Nakamura AJ, Gouliaeva K, Rahman A, Blakely WF and Bonner WM. The use of gamma-H2AX as a biodosimeter for total-body radiation exposure ? application for acute partial-body exposure dose assessments. PLoS One (2010) 5 (11) e15544.
  • Redon CE, Dickey JS, Nakamura AJ, Kareva IG, Naf D, Nowsheen S, Kalogerinis PK, Bonner WM, Georgakilas AG and Sedelnikova OA. Tumors induce complex DNA damage in proliferative tissues in vivo. Proc. Natl. Acad. Sci. U. S. A. (2010) 42: 17992-17997.
  • Nakamura AJ, Rao AV, Pommier Y and Bonner WM. The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks. Cell Cycle (2010) 2: 389-397.
  • Kobayashi Y, Sato K, Kibe T, Seimiya H, Nakamura A, Yukawa M, Tsuchiya E and Ueno M. Expression of mutant RPA in human cancer cells causes telomere shortening. Biosci Biotechnol Biochem. (2010) 74: 382-385.
  • Sordet O, Redon CE, Gourouilh-Barbat J, Smith S, Solier S, Douarre C, Conti C, Nakamura AJ, Das B, Nicolas E, Kohn K, Bonner WM and Pommier Y. ATM activation by transcription- and topoisomerase I-induced DNA double-strand breaks. EMBO report (2009) 8: 887-893.
  • Kumari D, Somma V, Nakamura AJ, Bonner WM, D’Ambrosio E and Usdin K. The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome. Nucleic Acids Res. (2009) 37: 4385-4392.
  • Nakamura AJ, Redon CE, Bonner WM and Sedelnikova OA. Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells. Aging (2009) 1: 212-218.
  • Nakamura AJ, Y. Chiang J, Hathcock KS, Horikawa I, Sedelnikova OA, Hodes RJ, Bonner WM. Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence. Epigenetics Chromatin (2008) 1 [Epub ahead of print].
  • Sedelnikova OA, Horikawa I, Redon C, Nakamura A, Zimonjic DB, Popescu NC, Bonner WM. Delayed kinetics of DNA double-strand break processing in normal and pathological aging. Aging Cell (2007) 7: 89-100.
  • Rao VA, Conti C, Guirouilh-Barbat J, Nakamura A, Miao Z-H, Davies SL, Sacca B, Hickson ID, Bensimon A and Pommier Y. Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase-deficient cells is related to DNA replication arrested forks. Mol. Cancer. Res. (2007) 5: 713-724.
  • Sedelnikova OA, Nakamura A, Kovalchuk O, Koturbash I, Mitchell SA, Marino SA, Brenner DJ and Bonner WM. DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models. Cancer Res. (2007) 67: 4295-4302.
  • Someya M, Sakata K, Tauchi H, Matsumoto Y, Nakamura A, Komatsu K, and Hareyama M. Association of Ionizing Radiation-Induced Foci of NBS1 with Chromosomal Instability and Breast Cancer Susceptibility. Radiation Res. (2006) 166: 575-582.

総説（抜粋）

  • Nakamura AJ. Assessment of radiation-induced DNA damage level using phosphorylated H2AX. Rad. Biol. Res. Commun. (2012) 47: 304-312. (Japanese)
  • Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA and Bonner WM. H2AX and DNA damage response. Curr. Cancer Res. (2011) 3-33.
  • Martin OA, Redon CE, Nakamura AJ, Dickey JS, Georgakilas AG, Bonner WM. Systemic DNA damage related to cancer. Cancer Res. (2011) 10:3437-3441.
  • Martin OA, Redon CE, Dickey JS, Nakamura AJ and Bonner WM. Para-inflammation mediates systemic DNA damage in response to tumor growth. Commun. Integr. Biol. (2011) 1:78-81.
  • Redon CE, Nakamura AJ, Zhang Y, Jiz J, Bonner WM, Kinders RJ, Parchments R, Doroshow JH and Pommier Y. Histone gamma-H2AX and poly(ADP ribose) as clinical pharmacodynamics biomarker. Clinical Cancer Res. (2010) 16: 4532-4542.
  • Nakamura AJ, Redon CE and Bonner WM. gamma-H2AX: applications for the evaluation of telomerase-based cancer therapy. Cell Cycle (2010) 9: 3385-3386.
  • Sedelnikova OA, Redon CE, Dickey JS, Nakamura AJ, Georgakilas AG and Bonner WM. Role of oxidatively-induced DNA lesions in human pathogenesis. Mutat. Res. (2010) 703: 152-159.
  • Dickey JS, Redon CE, Nakamura AJ, Baird BJ, Bonner WM and Sedelnikova OA. H2AX: functional role and potential applications. Chromosoma (2009) 118: 683-692.
  • Nakamura AJ, Redon CE and Sedelnikova OA. Where did they come from? The origins of endogenous gamma-H2AX foci in tumor cells. Cell Cycle (2009) 15: 2324.
  • Bonner WM, Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA, Solier S, Pommier, Y. gamma-H2AX and cancer. Nature Review Cancer (2008) 12: 957-967.

著書

  • Nakamura AJ. Assessment of DNA Damage Induction in Farm Animals After the FNPP Accident. "Low-Dose Radiation Effects on Animals and Ecosystems. Long-Term Study on the Fukushima Nuclear Accident" (2019): 153-161.
    https://link.springer.com/book/10.1007/978-981-13-8218-5
  • Nakamura AJ. Methods for the assessment of telomere status. Cell Senescence. Methods Mol. Biol. (2013) 965: 233-242.
  • Nakamura AJ, Parekh P, martin OA, Bonner WM and Redon CE. gamma-H2AX formation and chromatin structure. Advances in Genet. Res. Vol. 7 (2012) 127-152.
  • Dickey JS, Redon CE, Nakamura AJ, Baird BJ, Sedelnikova OA and Bonner WM. Stress and gamma-H2AX. Handbook of cell signaling, Regulation of organelle and Cell compartment Signalling. (2011) 309-319.
  • Redon CE, Nakamura AJ, Sordet O, Dickey JS, Gouliaeva K, Tabb B, Lawrence S, Kinders RJ, Bonner WM and Sedelnikova OA. gamma-H2AX detection peripheral blood lymphocytes, splenocytes, bone marrow, xenografts, and skin. Methods Mol. Biol. (2011) 682: 249-270.
  • Nakamura A, Sedelnikova OA, Redon C, Pilch DR, Sinogeeva NI, Shroff R, Michael L, and Bonner WM. Techniques for gamma-H2AX detection. Methods Emzymol. (2006) 409: 236-250.